Methyl 1-tert-Butoxycarbonyl-Piperidine-2-carboxylate
1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate
CAS: 167423-93-0
Molecular Formula: C12H21NO4
Methyl 1-tert-Butoxycarbonyl-Piperidine-2-carboxylate - Names and Identifiers
Methyl 1-tert-Butoxycarbonyl-Piperidine-2-carboxylate - Physico-chemical Properties
| Molecular Formula | C12H21NO4 |
| Molar Mass | 243.3 |
| Density | 1.094±0.06 g/cm3(Predicted) |
| Boling Point | 307.4±35.0 °C(Predicted) |
| Flash Point | 139.7°C |
| Vapor Presure | 0.000726mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow to Light orange |
| pKa | -3.28±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.46 |
Methyl 1-tert-Butoxycarbonyl-Piperidine-2-carboxylate - Introduction
1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate is an organic compound with the following properties:
1. Appearance: colorless liquid or white solid.
2. Molecular formula: C10H17NO3.
3. Molecular weight: 199.25g/mol.
4. Melting point: About 40-43 ° C.
5. Boiling Point: about 154-156 ° C.
6. Solubility: Soluble in organic solvents such as dimethyl amide and dichloromethane, insoluble in water.
1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate has a wide range of uses, including the following:
1. Protecting group in organic synthesis: it is often used as an amino protecting group, which can protect the amino group in amino compounds from reaction, so as to avoid side reactions.
2. Intermediate in drug synthesis: As an intermediate of piperidine derivatives, it is often used in drug synthesis, such as for the synthesis of anticancer drugs and other biologically active molecules.
3. Reagent in Chemical Research: It can be used as a reagent in organic synthesis research to study the synthetic path and reaction properties of compounds.
The preparation method of 1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate is roughly as follows:
Piperidine was dissolved in dimethyl thiourea, then methyl formate was added, left to react for a period of time, and finally distilled to collect the product. The specific reaction conditions can be adjusted according to the specific experimental design and needs.
It should be noted that 1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate should pay attention to the following safety information when using and storing:
1. Rinse with plenty of water immediately after contact with skin.
2. Avoid prolonged exposure to the air to avoid degradation reactions or the formation of explosive peroxides.
3. Should be operated in a well-ventilated place to avoid inhalation of its vapor or dust.
4. Please follow the correct laboratory practice and wear appropriate personal protective equipment, such as gloves, safety glasses, etc.
The information provided above is for reference only. Please strictly follow the relevant safety operating guidelines and laboratory regulations when handling and using the compound.
1. Appearance: colorless liquid or white solid.
2. Molecular formula: C10H17NO3.
3. Molecular weight: 199.25g/mol.
4. Melting point: About 40-43 ° C.
5. Boiling Point: about 154-156 ° C.
6. Solubility: Soluble in organic solvents such as dimethyl amide and dichloromethane, insoluble in water.
1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate has a wide range of uses, including the following:
1. Protecting group in organic synthesis: it is often used as an amino protecting group, which can protect the amino group in amino compounds from reaction, so as to avoid side reactions.
2. Intermediate in drug synthesis: As an intermediate of piperidine derivatives, it is often used in drug synthesis, such as for the synthesis of anticancer drugs and other biologically active molecules.
3. Reagent in Chemical Research: It can be used as a reagent in organic synthesis research to study the synthetic path and reaction properties of compounds.
The preparation method of 1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate is roughly as follows:
Piperidine was dissolved in dimethyl thiourea, then methyl formate was added, left to react for a period of time, and finally distilled to collect the product. The specific reaction conditions can be adjusted according to the specific experimental design and needs.
It should be noted that 1-tert-butyl 2-methyl piperidine-1,2-dicarboxylate should pay attention to the following safety information when using and storing:
1. Rinse with plenty of water immediately after contact with skin.
2. Avoid prolonged exposure to the air to avoid degradation reactions or the formation of explosive peroxides.
3. Should be operated in a well-ventilated place to avoid inhalation of its vapor or dust.
4. Please follow the correct laboratory practice and wear appropriate personal protective equipment, such as gloves, safety glasses, etc.
The information provided above is for reference only. Please strictly follow the relevant safety operating guidelines and laboratory regulations when handling and using the compound.
Last Update：2024-04-10 22:41:03
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